Affordable Access

Use of direct renin inhibitor in an HIV positive subject.

Authors
Type
Published Article
Journal
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive
Publication Date
Volume
20
Issue
1
Pages
49–51
Identifiers
PMID: 22475660
Source
Medline

Abstract

A 61-year-old HIV-infected Caucasian male (CDC C3) patient with hypertension for ten years and cardiovascular complications took carvedilol 25 mg twice a day, plus daily administration of irbesartan 300 mg, hydroclorotiazide 25 mg, doxazosin 4 mg, lacidipine 6 mg, and simvastatin 40 mg. He took AZT+ 3TC + RAL with a good profile on HIV replication and immunological parameters. We found a non-optimal blood pressure value and decided to start aliskiren 150 mg a day to improve blood pressure control. After one month blood pressure control and proteinuria improved. In our case the use of low doses of aliskiren appeared to improve the level of blood pressure, although five antihypertensive agents had already been used on the patient. Finally, although aliskiren would appear to have no direct effect on viro-immunological parameters and does not seem to interfere with cART, further studies are warranted in this context.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments