Use of Contemporary Protease Inhibitors and Risk of Incident Chronic Kidney Disease in Persons With Human Immunodeficiency Virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study.
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Authors
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Ryom, Lene1
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Dilling Lundgren, Jens1
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Reiss, Peter2, 3
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Kirk, Ole1
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Law, Matthew4
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Ross, Mike5
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Morlat, Phillip6
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Andreas Fux, Christoph7
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Fontas, Eric8
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De Wit, Stephane9
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D'Arminio Monforte, Antonella10
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El-Sadr, Wafaa11
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Phillips, Andrew12
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Ingrid Hatleberg, Camilla1
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Sabin, Caroline12
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Mocroft, Amanda12
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1
Rigshospitalet, University of Copenhagen, CHIP, Department of Infectious Diseases, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Copenhagen, Denmark.
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(Denmark)
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2
Amsterdam University Medical Centres (Location AMC), Department of Global Health and Division of Infectious Diseases, University of Amsterdam.
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3
HIV Monitoring Foundation, Amsterdam, The Netherlands.
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(Netherlands)
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4
Kirby Institute, University of New South Wales Sydney, Australia.
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(Australia)
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5
Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, and.
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6
Université de Bordeaux, INSERM.
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7
Clinic for Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Switzerland.
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(Switzerland)
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8
Department of Public Health, Nice University Hospital, France.
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(France)
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9
Division of Infectious Diseases, Saint Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
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(Belgium)
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10
Dipartimento di Scienze della Salute, Clinica di Malattie Infettive e Tropicali, Azienda Ospedaliera-Polo Universitario San Paolo, Milan, Italy.
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(Italy)
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11
ICAP at Columbia University and Harlem Hospital, New York.
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12
Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London, United Kingdom.
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(United Kingdom)
- Type
- Published Article
- Journal
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The Journal of Infectious Diseases
- Publisher
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Oxford University Press
- Publication Date
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Oct 08, 2019
- Volume
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220
- Issue
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10
- Pages
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1629–1634
- Identifiers
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DOI: 10.1093/infdis/jiz369
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PMID: 31504669
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
It is unclear whether use of contemporary protease inhibitors pose a similar risk of chronic kidney disease (CKD) as use of older protease inhibitors. Participants in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study were followed up until the earliest occurrence of CKD, the last visit plus 6 months, or 1 February 2016. Adjusted Poisson regression was used to assess associations between CKD and the use of ritonavir-boosted atazanavir (ATV/r) or ritonavir-boosted darunavir (DRV/r). The incidence of CKD (10.0/1000 person-years of follow-up; 95% confidence interval, 9.5-10.4/1000 person-years of follow-up) increased gradually with increasing exposure to ATV/r, but the relation was less clear for DRV/r. After adjustment, only exposure to ATV/r (adjusted incidence rate ratio, 1.4; 95% confidence interval, 1.2-1.6), but not exposure to DRV/r (1.0; .8-1.3), remained significantly associated with CKD. While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 10/16/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/31504669
