Affordable Access

deepdyve-link
Publisher Website

The Use of Codeine and Tramadol in the Pediatric Population-What is the Verdict Now?

Authors
  • Fortenberry, Megan
  • Crowder, Justin
  • So, Tsz-Yin
Type
Published Article
Journal
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
Publication Date
Jan 01, 2019
Volume
33
Issue
1
Pages
117–123
Identifiers
DOI: 10.1016/j.pedhc.2018.04.016
PMID: 30545525
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Codeine and tramadol are opioid analgesics approved for the management of pain in the United States. Both agents are metabolized in the liver to active compounds via the cytochrome P450 2D6 enzyme. Case reports of pediatric patients with overactive CYP2D6 enzymes have been reported. These ultra-rapid metabolizers experience an increase in the production of active metabolites of codeine and tramadol, which can lead to oversedation, respiratory depression, and death. In 2017, the U.S. Food and Drug Administration updated their warnings regarding codeine and tramadol use in the pediatric population, making their use contraindicated in patients under the age of 12 years. Copyright © 2018 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times