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The Use of Bone Marrow Concentrate in the Treatment of Full-Thickness Chondral Defects

Authors
  • Apostolakos, John M.1
  • Lazaro, Lionel1
  • Williams, Riley J.1
  • 1 Hospital for Special Surgery, Department of Orthopaedic Surgery, 535 East 70th Street, New York, NY, 10021, USA , New York (United States)
Type
Published Article
Journal
HSS Journal ®
Publisher
Springer US
Publication Date
Nov 26, 2018
Volume
15
Issue
1
Pages
96–99
Identifiers
DOI: 10.1007/s11420-018-9647-z
Source
Springer Nature
Keywords
License
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Abstract

This article is a critical analysis of a study, “Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model,” by Chu et al. (J Bone Joint Surg Am. 100(2):138–146, 2018). The investigation compared two interventions in the management of full-thickness chondral defects in an equine model: autologous bone marrow concentrate without concomitant microfracture treatment versus microfracture treatment alone. This review analyzes the methodology and results of their investigation and examines how their findings may influence the continued development of therapeutic options for full-thickness cartilage injuries. The study utilized in vitro analysis, arthroscopic assessment, magnetic resonance imaging (MRI) evaluation, and histological analysis to compare the treatments and their influence on the quality of cartilage repair. Although Chu et al. reported similar results between groups, their findings offer insight into the role of arthroscopy, MRI, and histology in the evaluation of repair quality. We compare their findings to those of similar investigations, highlighting the limited therapeutic options and variable clinical outcomes related to the treatment of full-thickness articular cartilage defects.

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