The aim of the study was to evaluate effectiveness of prophylactic antibiotics usage and the prevalence of infectious complications, after ocular surgery. Authors analyzed data from 53 ocular surgery centers in Poland: 28674 cases of cataract surgery, 6518 cases of complicated cataract surgery, 1387 cases of contemporary cataract and glaucoma surgery and 2978 cases of glaucoma surgery. The prevalence of endophthalmitis in this group of patients ranged from 0.29% after cataract surgery to 0.93% after complex surgery (cataract and glaucoma), and was higher than other studies show. This is because the study group was much smaller. The study is the first step to create optimal schema of antibiotics usage during ocular surgery. Rational antibiotics usage is very important because of worldwide growing antibiotic resistance.