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Use of [18F]FDG Positron Emission Tomography to Monitor the Development of Cardiac Allograft Rejection.

Authors
  • Daly, Kevin P
  • Dearling, Jason L J
  • Seto, Tatsuichiro
  • Dunning, Patricia
  • Fahey, Frederic
  • Packard, Alan B
  • Briscoe, David M
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Sep 01, 2015
Volume
99
Issue
9
Identifiers
DOI: 10.1097/TP.0000000000000618
PMID: 25675207
Source
Medline
License
Unknown

Abstract

PET imaging with [F]FDG can be used after transplantation to monitor the evolution of rejection. Decreased uptake of [N]NH3 in rejecting allografts may be reflective of decreased myocardial blood flow. These data suggest that combined [F]FDG and [N]NH3 PET imaging could be used as a noninvasive, quantitative technique for serial monitoring of allograft rejection and has potential application in human transplant recipients.

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