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Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential.

Authors
  • Gudoityte, Evelina1, 2
  • Arandarcikaite, Odeta1
  • Mazeikiene, Ingrida3
  • Bendokas, Vidmantas3
  • Liobikas, Julius1, 4
  • 1 Laboratory of Biochemistry, Neuroscience Institute, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania. , (Lithuania)
  • 2 Celignis Limited, Unit 11 Holland Road, Plassey Technology Park Castletroy, County Limerick, Ireland. , (Ireland)
  • 3 Lithuanian Research Centre for Agriculture and Forestry, Institute of Horticulture, Akademija, LT-58344 Kedainiai Distr., Lithuania. , (Lithuania)
  • 4 Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania. , (Lithuania)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Apr 27, 2021
Volume
22
Issue
9
Identifiers
DOI: 10.3390/ijms22094599
PMID: 33925641
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation and cell death-related pathways. Therefore, our aim was to review current studies on the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuroprotective effects in vitro and in vivo.

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