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Ursolic Acid provides kidney protection in diabetic rats.

Authors
  • Ling, Chen1
  • Jinping, Lu1
  • Xia, Li1
  • Renyong, Yang1
  • 1 Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China. , (China)
Type
Published Article
Journal
Current Therapeutic Research
Publisher
Elsevier
Publication Date
Dec 01, 2013
Volume
75
Pages
59–63
Identifiers
DOI: 10.1016/j.curtheres.2013.07.001
PMID: 24465045
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and the leading cause of end-stage renal failure. However, the treatment of DN is still a problem in the world. Inflammatory process plays a critical role in the development of DN. Therefore, anti-inflammatory treatment of DN is worth exploring now and in the future. The study aimed to evaluate the impact of ursolic acid (UA) on renal function in streptozotocin-induced diabetes. Rats with streptozotocin-induced diabetes were treated with UA for 16 weeks. After 16 weeks, urine albumin excretion, serum creatinine, and blood urea nitrogen were measured. In addition, renal oxidative stress level, nuclear factor kappa-B (NF-κB) activity, P-selectin expression, and kidney histopathologic changes were evaluated. Sixteen weeks following streptozotocin injection, the rats produced significant alteration in renal function and increased oxidative stress, NF-κB activity, and P-selectin expression in the kidneys. Interestingly, UA significantly prevented biochemical and histopathologic changes in the kidneys associated with diabetes. Compared with untreated diabetic rats, UA treatment lowered urine albumin excretion, renal oxidative stress level, NF-κB activity, and P-selectin expression. Moreover, UA treatment also improved renal histopathologic changes in rats with diabetes. UA treatment exhibited a protective effect on kidneys in diabetic rats, implying that UA could be a potential treatment for diabetic nephropathy.

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