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Urinary and renal interstitial concentrations of TNF-alpha increase prior to the rise in albuminuria in diabetic rats.

Authors
Type
Published Article
Journal
Kidney international
Publication Date
Volume
64
Issue
4
Pages
1208–1213
Identifiers
PMID: 12969138
Source
Medline
License
Unknown

Abstract

We found an early rise in renal TNF-alpha levels after induction of diabetes with STZ, which precedes the rise in UAE by about 2 weeks. These findings suggest a possible contribution of TNF-alpha in the complicated pathogenic process resulting in microalbuminuria in diabetes.

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