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Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study.

Authors
  • Lindhardt, Morten1
  • Persson, Frederik1
  • Zürbig, Petra2
  • Stalmach, Angelique3
  • Mischak, Harald2, 3
  • de Zeeuw, Dick4
  • Lambers Heerspink, Hiddo4
  • Klein, Ronald5
  • Orchard, Trevor6
  • Porta, Massimo7
  • Fuller, John8
  • Bilous, Rudolf9, 10
  • Chaturvedi, Nish11
  • Parving, Hans-Henrik12
  • Rossing, Peter1, 13, 14
  • 1 Steno Diabetes Center, Gentofte, Denmark. , (Denmark)
  • 2 Mosaiques Diagnostics GmbH, Hannover, Germany. , (Germany)
  • 3 University of Glasgow, Glasgow, UK.
  • 4 Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. , (Netherlands)
  • 5 Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • 6 Department of Epidemiology, Medicine & Pediatrics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • 7 Department of Medical Sciences, University of Turin, Torino, Italy. , (Italy)
  • 8 Department of Epidemiology and Public Health, University College London, London, UK.
  • 9 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
  • 10 South Tees NHS Trust, Middlesbrough, UK.
  • 11 Institute of Cardiovascular Sciences, University College London, London, UK.
  • 12 Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 13 Faculty of Health Science, University of Aarhus, Aarhus, Denmark. , (Denmark)
  • 14 The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
Type
Published Article
Journal
Nephrology Dialysis Transplantation
Publisher
Oxford University Press
Publication Date
Nov 01, 2017
Volume
32
Issue
11
Pages
1866–1873
Identifiers
DOI: 10.1093/ndt/gfw292
PMID: 27507891
Source
Medline
Keywords
License
Unknown

Abstract

In this cohort of patients with type 2 diabetes and normoalbuminuria from a large intervention study, the CKD273-classifier was an independent predictor of microalbuminuria. This may help identify high-risk normoalbuminuric patients for preventive strategies for diabetic nephropathy.

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