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Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases.

Authors
  • Wei, Pascal Zhongping1
  • Kwan, Bonnie Ching-Ha1
  • Chow, Kai Ming1
  • Cheng, Phyllis Mei-Shan1
  • Luk, Cathy Choi-Wan1
  • Lai, Ka-Bik1
  • Li, Philip Kam-To1
  • Szeto, Cheuk Chun2
  • 1 Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. , (China)
  • 2 Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Clinica chimica acta; international journal of clinical chemistry
Publication Date
May 17, 2018
Volume
484
Pages
36–39
Identifiers
DOI: 10.1016/j.cca.2018.05.036
PMID: 29778542
Source
Medline
Keywords
License
Unknown

Abstract

Mitochondrial DNA is readily detectable in the urinary supernatant of non-diabetic CKD, and its level correlates with the rate of renal function decline and predicts the risk of doubling of serum creatinine or need of dialysis. Further studies are needed to determine the value of urinary supernatant mtDNA level as a prognostic indicator of non-diabetic CKD.

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