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Urinary metabolites of furan in waterpipe tobacco smokers compared to non-smokers in home settings in the US.

Authors
  • Kassem, Nada O F1
  • Peterson, Lisa A2
  • Liles, Sandy3
  • Kassem, Noura O3
  • Zaki, Flora K3
  • Lui, Kung-Jong4
  • Vevang, Karin R2
  • Dodder, Nathan G4
  • Hoh, Eunha5
  • Hovell, Melbourne F3
  • 1 Center for Behavioral Epidemiology and Community Health (CBEACH), Hookah Tobacco Studies Division, San Diego State University Research Foundation, San Diego, CA, 92123, United States. Electronic address: [email protected] , (United States)
  • 2 Division of Environmental Health Sciences and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, United States. , (United States)
  • 3 Center for Behavioral Epidemiology and Community Health (CBEACH), Hookah Tobacco Studies Division, San Diego State University Research Foundation, San Diego, CA, 92123, United States. , (United States)
  • 4 San Diego State University Research Foundation, 5250 Campanile Dr., San Diego, CA 92182, United States. , (United States)
  • 5 School of Public Health, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182, United States. , (United States)
Type
Published Article
Journal
Toxicology letters
Publication Date
Aug 16, 2020
Volume
333
Pages
202–210
Identifiers
DOI: 10.1016/j.toxlet.2020.08.002
PMID: 32814080
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Determine uptake of furan, a potential human carcinogen, in waterpipe tobacco (WPT) smokers in home settings. We analysed data from a US convenience sample of 50 exclusive WPT smokers, mean age 25.3 years, and 25 non-smokers, mean age 25.5 years. For WPT smokers, data were collected at a home visit by research assistants during which participants smoked one WPT head of one brand for a mean of 33.1 min in their homes. Research assistants provided and prepared a WP for participants by weighing and loading 10 g of WPT in the WP head. At the completion of the smoking session, research assistants measured the remaining WPT. Cotinine and six furan metabolites were quantified in first morning urine samples provided on 2 consecutive days for non-smokers, and on the morning of a WPT smoking session and on the following morning for smokers. WPT smokers consumed a mean of 2.99 g WPT. In WPT smokers, urinary cotinine levels increased significantly 26.1 times the following morning; however, urinary metabolites of furan did not increase significantly. Compared to non-smokers, 2 furan metabolites, N-acetyl-S-[1-(5-acetylamino-5-carboxylpentyl)-1H-pyrrol-3-yl]-L-cysteine and N-acetyl-S-[1-(5-amino-5-carboxypentyl)-1H-pyrrol-3-yl]-L-cysteine sulfoxide, were significantly higher in WPT smokers in pre and in post WPT smoking levels. To enable a more rigorous assessment of furan exposure from WPT smoking, future research should determine furan concentrations in WPT smoke, quantify furan metabolites from users of various WPT brands; and extend the investigation to social settings where WPT smoking is habitually practiced. Copyright © 2020 Elsevier B.V. All rights reserved.

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