Affordable Access

Uptake and distribution of halothane in infants: in vivo measurements and computer simulations.

Authors
  • Brandom, B W
  • Brandom, R B
  • Cook, D R
Type
Published Article
Journal
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia
Publication Date
Apr 01, 1983
Volume
62
Issue
4
Pages
404–410
Identifiers
PMID: 6829943
Source
Medline
License
Unknown

Abstract

We measured uptake of halothane (the fraction of halothane in expired gas divided by the fraction of halothane in inspired gas, FE/FI) with a mass spectrometer over time in 7 infants less than 3 months of age. FE/FI for halothane in these infants increased more rapidly than has been described in adults by others. In addition, we developed a mathematical model for halothane uptake and distribution that incorporates age-dependent anatomic and physiologic parameters (alveolar ventilation, functional residual capacity, cardiac output, brain volume, etc). The model closely predicts FE/FI for halothane measured in the infants. At 5 min observed FE/FI was 0.67, at 15 min observed FE/FI was 0.80, while the predicted FE/FI values were 0.65 and 0.82, respectively. The model predicts that the myocardial and brain halothane concentrations will increase more rapidly in the infant than in the adult. Achievement of high myocardial halothane concentrations early in the anesthetic induction may cause the hypotension and bradycardia commonly seen in infants. Sensitivity of the infant myocardium to halothane would further exacerbate the effect of more rapid myocardial uptake.

Report this publication

Statistics

Seen <100 times