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Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins.

Authors
  • Zhang, He1
  • Guo, Jun1
  • Mao, Liping1
  • Li, Qianqian1
  • Guo, Mengnan1
  • Mu, Teng1
  • Zhang, Qiuhua2
  • Bi, Xiuli1, 3
  • 1 College of Life Science, Liaoning University, Shenyang 110036, People's Republic of China. , (China)
  • 2 Department of Pharmacology, Liaoning University of Traditional Chinese Medicine, Shenyang 110036, People's Republic of China. , (China)
  • 3 Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province, Liaoning University, Shenyang 110036, People's Republic of China. , (China)
Type
Published Article
Journal
British Journal Of Nutrition
Publisher
Cambridge University Press
Publication Date
Sep 14, 2019
Volume
122
Issue
5
Pages
518–526
Identifiers
DOI: 10.1017/S0007114518003136
PMID: 30375302
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

As important epigenetic regulators, microRNA regulate protein expression by triggering the degradation of target mRNA and/or by inhibiting their translation. Dysregulation of microRNA expression has been reported in several cancers, including colorectal cancer. In this study, microRNA-array differential analysis revealed strongly enhanced expression of miR-24-1-5p in the colon tissue of azoxymethane/dextran sulphate sodium-induced mice that were fed with black raspberry anthocyanins for 9 weeks. Overexpression of miR-24-1-5p in human colorectal cancer cells significantly repressed β-catenin expression, and simultaneously decreased cell proliferation, migration and survival. Furthermore, miR-24-1-5p could target β-catenin and trigger a negative regulatory loop for β-catenin and its downstream target genes. β-Catenin signalling is vital to the formation and progression of human colorectal cancer. The current findings therefore identified miR-24-1-5p as a potent regulator of β-catenin, and this may provide a novel chemopreventive and therapeutic strategy for β-catenin signalling-driven colorectal cancer.

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