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Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: In vitro and in vivo

Authors
  • Hu, Xiang
  • Liu, Yang
  • Qin, Chunxia
  • Pan, Zhenyu
  • Luo, Jun
  • Yu, Aixi
  • Cheng, Zhen1, 2, 3, 4, 5, 6, 7, 2
  • 1 Department of Orthopedics
  • 2 Zhongnan Hospital of Wuhan University
  • 3 Molecular Imaging Program at Stanford
  • 4 Canary Center at Stanford for Cancer Early Detection
  • 5 Department of Radiology and Bio-X Program
  • 6 Stanford University
  • 7 Department of Pathology
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2013
Accepted Date
Dec 13, 2013
Volume
346
Issue
1
Pages
114–121
Identifiers
DOI: 10.1016/j.canlet.2013.12.020
Source
Elsevier
Keywords
License
Unknown

Abstract

Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In addition, we observed in vitro anti-proliferation and pro-apoptosis effects of up-regulated IDH1 on osteosarcoma cell lines. The migration and invasion activity was also markedly reduced by IDH1 up-regulation. Unexpectedly, IDH1 up-regulation also suppressed tumor growth and metastasis in vivo. Therefore, IDH1 may represent a potential novel treatment and preventive strategy for osteosarcoma.

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