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An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties.

  • Ahmad, Md Faruque1
  • Ahmad, Fakhruddin Ali2
  • Ashraf, Syed Amir3
  • Saad, Hisham H1
  • Wahab, Shadma4
  • Khan, Mohammed Idreesh5
  • Ali, M6
  • Mohan, Syam7
  • Hakeem, Khalid Rehman8
  • Athar, Md Tanwir9, 10
  • 1 Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Saudi Arabia. , (Saudi Arabia)
  • 2 Department of Laboratory Medicine Al-Hada and Taif Military Hospital, Saudi Arabia. , (Saudi Arabia)
  • 3 Dept. of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Saudi Arabia. , (Saudi Arabia)
  • 4 College of Pharmacy, King Khalid University, Abha, Saudi Arabia. , (Saudi Arabia)
  • 5 Department of Clinical Nutrition, College of Applied Health Sciences in Arras, Qassim University, Saudi Arabia. , (Saudi Arabia)
  • 6 College of pharmacy, Dept. of Pharmacognosy, Jazan University, Saudi Arabia. , (Saudi Arabia)
  • 7 Medical Research Center, Jazan University, Jazan, Saudi Arabia. , (Saudi Arabia)
  • 8 Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. , (Saudi Arabia)
  • 9 Bioactive Natural Product Laboratory, Hamdard University, India. , (India)
  • 10 Scientific Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. , (Saudi Arabia)
Published Article
Journal of herbal medicine
Publication Date
Feb 01, 2021
DOI: 10.1016/j.hermed.2020.100404
PMID: 32983848


N. sativa (N. sativa) has been used since ancient times, when a scientific concept about the use of medicinal plants for the treatment of human illnesses and alleviation of their sufferings was yet to be developed. It has a strong religious significance as it is mentioned in the religious books of Islam and Christianity. In addition to its historical and religious significance, it is also mentioned in ancient medicine. It is widely used in traditional systems of medicine for a number of diseases including asthma, fever, bronchitis, cough, chest congestion, dizziness, paralysis, chronic headache, back pain and inflammation. The importance of this plant led the scientific community to carry out extensive phytochemical and biological investigations on N. sativa. Pharmacological studies on N. sativa have confirmed its antidiabetic, antitussive, anticancer, antioxidant, hepatoprotective, neuro-protective, gastroprotective, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator activity. The present review is an effort to explore the reported chemical composition and pharmacological activity of this plant. It will help as a reference for scientists, researchers, and other health professionals who are working with this plant and who need up to date knowledge about it. © 2020 Elsevier GmbH. All rights reserved.

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