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Update on Osteosarcoma

Authors
  • Belayneh, Rebekah1
  • Fourman, Mitchell S.1
  • Bhogal, Sumail1
  • Weiss, Kurt R.1
  • 1 University of Pittsburgh Medical Center, Pittsburgh, PA, USA , Pittsburgh (United States)
Type
Published Article
Journal
Current Oncology Reports
Publisher
Springer-Verlag
Publication Date
Apr 21, 2021
Volume
23
Issue
6
Identifiers
DOI: 10.1007/s11912-021-01053-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewOsteosarcoma (OSA) is the most common primary tumor of bone, mainly affecting children and adolescents. Here we discuss recent advances in surgical and systemic therapies, and highlight potentially new modalities in preclinical evaluation and prognostication.Recent FindingsThe advent of neoadjuvant and adjuvant chemotherapy has markedly improved the disease-free recurrence and overall survival of OSA. However, treatment efficacy has been stagnant since the 1980s. This plateau has prompted preclinical and clinical research into in precision surgery, inhaled chemotherapy to increase pulmonary drug concentration without systemic side effects, and novel immunomodulators intended to block molecular pathways associated with OSA proliferation and metastasis.SummaryWith the advent of novel surgical techniques and new forms and vectors for chemotherapy, it is hoped that OSA treatment outcomes will exceed their currently sustained plateau in the near future.

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