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Update on islet transplantation.

Authors
  • McCall, Michael
  • Shapiro, A M James
Type
Published Article
Journal
Cold Spring Harbor Perspectives in Medicine
Publisher
Cold Spring Harbor Laboratory
Publication Date
Jul 01, 2012
Volume
2
Issue
7
Identifiers
DOI: 10.1101/cshperspect.a007823
PMID: 22762022
Source
Medline
License
Unknown

Abstract

Clinical islet transplantation has progressed considerably over the past 12 years, and >750 patients with type 1 diabetes have received islet transplants internationally over this time. Many countries are beginning to accept the transition from research to accepted and funded clinical care, especially for patients with brittle control that cannot be stabilized by more conventional means. Major challenges remain, including the need for more than one donor, and the requirement for potent, chronic immunosuppression. Combining immunological tolerance both to allo- and autoantigens, and a limitless expandable source of stem cell- or xenograft-derived insulin-secreting cells represent remaining hurdles in moving this effective treatment to a potential cure for all those with type 1 or 2 diabetes.

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