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Update on the Current Status and Indications for Transcatheter Edge-to-Edge Mitral Valve Repair

Authors
  • Qintar, Mohammed1, 2
  • Chhatriwalla, Adnan K.2
  • 1 Henry Ford Health System, Detroit, MI, USA , Detroit (United States)
  • 2 Saint Luke’s Mid America Heart Institute and University of Missouri-Kansas City, 4401 Wornall Road, Kansas City, MO, 64111, USA , Kansas City (United States)
Type
Published Article
Journal
Current Cardiology Reports
Publisher
Springer-Verlag
Publication Date
Sep 10, 2020
Volume
22
Issue
11
Identifiers
DOI: 10.1007/s11886-020-01391-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewTo review the current status and indications of transcatheter edge-to-edge mitral valve repair.Recent FindingsMitral regurgitation remains a common valvular disease and can be classified as degenerative (primary) or functional (secondary). Randomized controlled trials have shown that transcatheter edge-to-edge mitral valve repair with MitraClip is successful, safe, and effective in reducing mitral regurgitation. The US Food and Drug Administration approved MitraClip in 2013 for treatment of patients with primary mitral regurgitation at prohibitive surgical risk and in 2019 for secondary mitral regurgitation. Several MitraClip generations exist (NT/R, XT/R, NTW, and XTW) with unique features and considerations. Additional edge-to-edge repair, non-edge-to-edge repair, and transcatheter valve replacement systems are under investigation as stand-alone or adjunctive therapy for patients with mitral regurgitation.SummaryMitral regurgitation remains a significant health burden and many patients are not suitable for surgical repair or replacement. Transcatheter mitral valve therapies can be considered in selected patients and are safe and effective. More research is needed to understand how to best select devices and patients and optimize outcomes.

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