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The insulin receptor translocates to the nucleus to regulate cell proliferation in liver.

Authors
  • Amaya, Maria J
  • Oliveira, André G
  • Guimarães, Erika S
  • Casteluber, Marisa C F
  • Carvalho, Sandhra M
  • Andrade, Lidia M
  • Pinto, Mauro C X
  • Mennone, Albert
  • Oliveira, Cleida A
  • Resende, Rodrigo R
  • Menezes, Gustavo B
  • Nathanson, Michael H
  • Leite, M Fatima
Type
Published Article
Journal
Hepatology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2014
Volume
59
Issue
1
Pages
274–283
Identifiers
DOI: 10.1002/hep.26609
PMID: 23839970
Source
Medline
License
Unknown

Abstract

These findings provide evidence that insulin's mitogenic effects are mediated by a subpopulation of IRs that traffic to the nucleus to locally activate InsP3 -dependent Ca(2+)-signaling pathways. The steps along this signaling pathway reveal a number of potential targets for therapeutic modulation of liver growth in health and disease.

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