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Up-regulation of expression and lack of 5' CpG island hypermethylation of p16 INK4a in HPV-positive cervical carcinomas.

Authors
  • Ivanova, Tatiana A
  • Golovina, Daria A
  • Zavalishina, Larisa E
  • Volgareva, Galina M
  • Katargin, Alexey N
  • Andreeva, Yulia Y
  • Frank, Georgy A
  • Kisseljov, Fjodor L
  • Kisseljova, Natalia P
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2007
Volume
7
Pages
47–47
Identifiers
PMID: 17359536
Source
Medline
License
Unknown

Abstract

Hypermethylaion of the p16INK4a 5' CpG island is not a frequent event in HR-HPV-positive cervical carcinomas and cannot be an effective marker of cancer cells with up-regulated expression of p16ink4a. Our data confirm other previous studies claiming specific p16INK4a up-regulation in the majority of cervical carcinomas at both the protein and mRNA levels. Cytoplasmic accumulation of p16ink4a is a feature of cervical carcinomas.

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