The papillary carcinoma is the most common cancer of thyroid but its presentation may be unexpected. In the first case, a 18-year-old girl complained of a painful enlargement of the right thyroid lobe. Upon the basis of a CT scan revealing punctuate calcifications suggesting psammoma bodies and a right-sided cold nodule on thyroid radioiodine scanning, the patient had a thyroidectomy. The second case was a discovery of papillary carcinoma in a 49-year-old woman who had a thyroidectomy for Graves' disease. This association may not be fortuitous. The cancer could be more aggressive in this group of patients, as TSI play a pathogenic role.