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An unusual case of Hansen's disease (lepromatous leprosy) with circulating anticoagulant and macroglobulinemia.

Authors
Type
Published Article
Journal
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
Publication Date
Volume
58
Issue
3
Pages
462–465
Identifiers
PMID: 2119410
Source
Medline

Abstract

A 42-year-old Mexican migrant laborer with a previous history of neurofibromatosis presented with a stuffy nose and chronic ulceration of his soft palate. Multiple subcutaneous nodules were found on his skin, and laboratory investigation revealed an elevated activated partial thromboplastin time (APTT). Further laboratory evaluation showed a lupus-like circulating anticoagulant deemed IgM by quantitative immunoglobulin studies. Although coagulation defects in lepromatous leprosy are rare, the preoperative preparation of a patient with leprosy may require a screening prothrombin time (PT), APTT and platelet count. Abnormalities in these values may indicate the need for specific factor assays and a search for circulating anticoagulant.

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