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Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma

Authors
  • Palamidessi, Andrea1
  • Malinverno, Chiara1, 2
  • Frittoli, Emanuela1
  • Corallino, Salvatore1
  • Barbieri, Elisa3
  • Sigismund, Sara2, 3
  • Beznoussenko, Galina V.1
  • Martini, Emanuele1
  • Garre, Massimiliano1
  • Ferrara, Ines4
  • Tripodo, Claudio1, 4
  • Ascione, Flora1
  • Cavalcanti-Adam, Elisabetta A.5
  • Li, Qingsen1
  • Di Fiore, Pier Paolo2, 3
  • Parazzoli, Dario1
  • Giavazzi, Fabio6
  • Cerbino, Roberto6
  • Scita, Giorgio1, 2
  • 1 IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy , Milan (Italy)
  • 2 University of Milan, Department of Oncology and Hemato-Oncology, Milan, Italy , Milan (Italy)
  • 3 Istituto Europeo di Oncologia IRCCS, Milan, Italy , Milan (Italy)
  • 4 University of Palermo School of Medicine, Department of Health Sciences, Human Pathology Section, Palermo, Italy , Palermo (Italy)
  • 5 Max Planck Institute for Medical Research, Heidelberg, Germany , Heidelberg (Germany)
  • 6 University of Milan, Department of Medical Biotechnology and Translational Medicine, Segrate, Italy , Segrate (Italy)
Type
Published Article
Journal
Nature Materials
Publisher
Springer Nature
Publication Date
Jul 22, 2019
Volume
18
Issue
11
Pages
1252–1263
Identifiers
DOI: 10.1038/s41563-019-0425-1
Source
Springer Nature
License
Yellow

Abstract

A RAB5A-mediated, epidermal growth factor-dependent activation of endosomal ERK1/2 is identified as a key molecular route for a solid-to-liquid-like phase transition, sufficient to overcome kinetic and proliferation arrest in normal mammary epithelial assemblies and to promote collective invasion in breast carcinoma.

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