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Unique NS5b Hepatitis C Virus Gene Sequence Consensus Database Is Essential for Standardization of Genotype Determinations in Multicenter Epidemiological Studies

Authors
  • Syria Laperche
  • Karine Saune
  • Paul Dény
  • Gilles Duverlie
  • Sophie Alain
  • Marie-Laure Chaix
  • Catherine Gaudy
  • Françoise Lunel
  • Jean-Michel Pawlotsky
  • Christopher Payan
  • Bruno Pozzetto
  • Catherine Tamalet
  • Vincent Thibault
  • Sophie Vallet
  • Françoise Bouchardeau
  • Jacques Izopet
  • Jean-Jacques Lefrère
Publisher
American Society for Microbiology
Publication Date
Feb 01, 2006
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

A multicenter study of NS5b hepatitis C virus (HCV) genotype determination involving 12 laboratories demonstrates that any laboratory with expertise in sequencing techniques would be able to provide a reliable HCV genotype for clinical and epidemiological purposes as long as they are provided a consensus reference sequence database.

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