A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5
- Authors
- Type
- Published Article
- Journal
- PLoS Biology
- Publisher
- Public Library of Science
- Publication Date
- Aug 31, 2021
- Volume
- 19
- Issue
- 8
- Identifiers
- DOI: 10.1371/journal.pbio.3001371
- PMID: 34464377
- PMCID: PMC8407551
- Source
- PubMed Central
- Disciplines
- License
- Unknown
Abstract
In this issue of PLOS Biology , Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.
