Affordable Access

deepdyve-link
Publisher Website

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

Authors
  • Mocarski, Edward S.
  • Mandal, Pratyusha
Type
Published Article
Journal
PLoS Biology
Publisher
Public Library of Science
Publication Date
Aug 31, 2021
Volume
19
Issue
8
Identifiers
DOI: 10.1371/journal.pbio.3001371
PMID: 34464377
PMCID: PMC8407551
Source
PubMed Central
Disciplines
  • Biology and Life Sciences
  • Cell Biology
  • Signal Transduction
  • Cell Signaling
License
Unknown

Abstract

In this issue of PLOS Biology , Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.

Report this publication

Statistics

Seen <100 times