Affordable Access

deepdyve-link
Publisher Website

A unique cardiac cytosolic acyltransferase with preferential selectivity for fatty acids that form cyclooxygenase/lipoxygenase metabolites and reverse essential fatty acid deficiency

Authors
  • Needleman, Philip
  • Wyche, Angela
  • Sprecher, Howard
  • Elliott, William J.
  • Evers, Alex
Type
Published Article
Journal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier
Publication Date
Jan 01, 1985
Volume
836
Issue
2
Pages
267–273
Identifiers
DOI: 10.1016/0005-2760(85)90075-X
Source
Elsevier
Keywords
License
Unknown

Abstract

The rabbit heart contains a cytosolic enzyme which selectively incorporates polyunsaturated fatty acids into phosphatidylcholine. This unique acyltransferase is selective for fatty acids, thus far tested, that are substrates for cyclooxygenase or lipoxygenase (i.e., arachidonic, eicosapentaenoic, linoleic and dihomo-γ-linoleic acids) or which reverse the symptoms of essential fatty acid deficiency (columbinic acid). On the other hand, palmitic, oleic, 5,8,11-eicosatrienoic ( n − 9, Mead acid), and docosatetraenoic acid ( n − 6, adrenic acid) were not incorporated in phospholipids by the cytosolic acyltransferase. No such fatty acid selectivity was exhibited by the cytosolic acyl-CoA synthetase or by the acyltransferase activities present in cardiac microsomes and mitochondria.

Report this publication

Statistics

Seen <100 times