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Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology.

Authors
  • Wood, P L
  • Pilapil, C
  • LaFaille, F
  • Nair, N P
  • Glennon, R A
Type
Published Article
Journal
Archives internationales de pharmacodynamie et de thérapie
Publication Date
Apr 01, 1984
Volume
268
Issue
2
Pages
194–201
Identifiers
PMID: 6732364
Source
Medline
License
Unknown

Abstract

[3H]Tryptamine binding in rat brain is widely distributed with highest densities in the cortex, striatum and hippocampus. This binding is stereospecific and is potently displaced by tryptamine analogues and beta-carbolines. Phenethylamines also possess a weaker activity in displacing [3H]tryptamine. The strict structural requirements for binding to this site substantiate its unique character and suggest that it may represent a tryptamine receptor in the CNS.

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