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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.

Authors
  • Hassan-Mohamed, I
  • Giorgio, C
  • Incerti, M
  • Russo, S
  • Pala, D
  • Pasquale, E B
  • Zanotti, I
  • Vicini, P
  • Barocelli, E
  • Rivara, S
  • Mor, M
  • Lodola, A
  • Tognolini, M
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2014
Volume
171
Issue
23
Pages
5195–5208
Identifiers
DOI: 10.1111/bph.12669
PMID: 24597515
Source
Medline
License
Unknown

Abstract

The discovery of UniPR129 represents not only a major advance in potency compared with the existing Eph-ephrin antagonists but also an improvement in terms of cytotoxicity, making this molecule a useful pharmacological tool and a promising lead compound.

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