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Unintended consequences of infection prevention and control measures during COVID-19 pandemic

Authors
  • Wee, Liang En1, 2
  • Conceicao, Edwin Philip3
  • Tan, Jing Yuan4
  • Magesparan, Kamini Devi3
  • Amin, Ismawati Binte Mohamad3
  • Ismail, Bushra Binte Shaik3
  • Xian, Toh Hui3
  • Pinhong, Jin3
  • Jing, Zhang5
  • Elaine, Wee Geok Ling3
  • Ong, Sheena Jin Min3
  • Lee, Gillian Li Xin3
  • Wang, Amanda En-min5
  • Bien, Molly How Kue3
  • Yuen, Tan Kwee3
  • Chee, Lee Lai3
  • Choo, Phoon Poh5
  • Yong, Yang3
  • Aung, May Kyawt3
  • Sim, Xiang Ying Jean2, 3
  • And 2 more
  • 1 Singhealth Infectious Diseases Residency, Singapore
  • 2 Department of Infectious Diseases, Singapore General Hospital, Singapore
  • 3 Department of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore
  • 4 Department of Internal Medicine, Singapore General Hospital, Singapore
  • 5 Department of Nursing Speciality Care Unit, National Heart Centre, Singapore
Type
Published Article
Journal
American Journal of Infection Control
Publisher
Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.
Publication Date
Nov 04, 2020
Identifiers
DOI: 10.1016/j.ajic.2020.10.019
PMCID: PMC7610096
Source
PubMed Central
Keywords
License
Unknown

Abstract

Background In the current COVID-19 pandemic, aggressive Infection Prevention and Control (IPC) measures have been adopted to prevent healthcare-associated transmission of COVID-19. We evaluated the impact of a multi-modal IPC strategy originally designed for the containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs). Methodology From February-August 2020, a multi-modal IPC strategy was implemented across a large healthcare campus in Singapore, comprising improved segregation of patients with respiratory symptoms, universal masking and heightened adherence to Standard Precautions. The following rates of HAI were compared pre- and post-pandemic: healthcare-associated respiratory-viral-infection (HA-RVI), MRSA and CP-CRE acquisition rates, healthcare-facility-associated C.difficile infections (HCFA-CDI) and device-associated HAIs. Results Enhanced IPC measures introduced to contain COVID-19 had the unintended positive consequence of containing HA-RVI. The cumulative incidence of HA-RVI decreased from 9.69 cases per 10,000 patient-days to 0.83 cases per 10,000 patient-days (incidence-rate-ratio=0.08; 95%CI=0.05-0.13, p<0.05). Hospital-wide MRSA acquisition rates declined significantly during the pandemic (incidence-rate-ratio=0.54, 95%CI=0.46-0.64, p<0.05), together with central-line-associated-bloodstream infection (CLABSI) rates (incidence-rate-ratio=0.24, 95%CI=0.07-0.57, p<0.05); likely due to increased compliance with Standard Precautions. Despite the disruption caused by the pandemic, there was no increase in CP-CRE acquisition, and rates of other HAIs remained stable. Conclusion Multimodal IPC strategies can be implemented at scale to successfully mitigate healthcare-associated transmission of RVIs. Good adherence to personal-protective-equipment and hand hygiene kept other HAI rates stable even during an ongoing pandemic where respiratory infections were prioritized for interventions.

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