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The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry.

Authors
  • Pierucci, Massimo1
  • Di Matteo, Vincenzo
  • Benigno, Arcangelo
  • Crescimanno, Giuseppe
  • Esposito, Ennio
  • Di Giovanni, Giuseppe
  • 1 Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy. , (Italy)
Type
Published Article
Journal
Annals of the New York Academy of Sciences
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2009
Volume
1155
Pages
316–323
Identifiers
DOI: 10.1111/j.1749-6632.2008.03679.x
PMID: 19250223
Source
Medline
License
Unknown

Abstract

6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.

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