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Undulating tubular liposomes through incorporation of a synthetic skin ceramide into phospholipid bilayers.

Authors
  • Xu, Peng
  • Tan, Grace
  • Zhou, Jia
  • He, Jibao
  • Lawson, Louise B
  • McPherson, Gary L
  • John, Vijay T
Type
Published Article
Journal
Langmuir : the ACS journal of surfaces and colloids
Publication Date
Sep 15, 2009
Volume
25
Issue
18
Pages
10422–10425
Identifiers
DOI: 10.1021/la9010899
PMID: 19694462
Source
Medline
License
Unknown

Abstract

Nonspherical liposomes were prepared by doping L-alpha-phosphatidylcholine (PC) with ceramide VI (a skin lipid). Cryo-transmission electron microscopy shows the liposome shape changing from spherical to an undulating tubular morphology, when the amount of ceramide VI is increased. The formation of tubular liposomes is energetically favorable and is attributed to the association of ceramide VI with PC creating regions of lower curvature. Since ceramides are the major component of skin lipids in the stratum corneum, tubular liposomes containing ceramide may potentially serve as self-enhanced nanocarriers for transdermal delivery.

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