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Understanding Vulnerable Plaques: Current Status and Future Directions.

Authors
  • Lee, Kwan Yong1
  • Chang, Kiyuk2
  • 1 Cardiovascular Center and Cardiology Division, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. , (North Korea)
  • 2 Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. [email protected] , (North Korea)
Type
Published Article
Journal
Korean circulation journal
Publication Date
Dec 01, 2019
Volume
49
Issue
12
Pages
1115–1122
Identifiers
DOI: 10.4070/kcj.2019.0211
PMID: 31760703
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The main cause of acute myocardial infarction is plaque rupture accompanied by superimposed coronary thrombosis. Thin-cap fibroatheromas (TCFAs) have been suggested as a type of lesion with a vulnerability that can cause plaque rupture. However, not only the existence of a TCFA but also the fine and complex interactions of other anatomical and hemodynamic factors, such as microcalcification in the fibrous cap, cholesterol crystal-induced inflammasome activation, the apoptosis of intraplaque macrophages, and endothelial shear stress distribution should precede a clinical event caused by plaque rupture. Recent studies are being conducted to identify these mechanisms through molecular imaging and hemodynamic assessment using computational fluid dynamics, which will result in better clinical results through selective coronary interventions. Copyright © 2019. The Korean Society of Cardiology.

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