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Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes

Authors
  • Manna, Moutusi
  • Nieminen, Tuomo
  • Vattulainen, Ilpo
Type
Published Article
Journal
Annual Review of Biophysics
Publisher
Annual Reviews
Publication Date
May 06, 2019
Volume
48
Pages
421–439
Identifiers
DOI: 10.1146/annurev-biophys-052118-115553
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Cell signaling controls essentially all cellular processes. While it is often assumed that proteins are the key architects coordinating cell signaling, recent studies have shown more and more clearly that lipids are also involved in signaling processes in a number of ways. Lipids do, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control membrane receptor partitioning. Further, through structural modifications such as oxidation, the functions of lipids as part of signaling processes can be modified. In this context, in this article we discuss the understanding recently revealed by atomistic and coarse-grained computer simulations of nanoscale processes and underlying physicochemical principles related to lipids’ functions in cellular signaling.

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