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Understanding the influence of experimental factors on bio-interactions of nanoparticles: Towards improving correlation between in vitro and in vivo studies

Authors
  • Natarajan, Pavithra
  • Tomich, John M.
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
Sep 21, 2020
Volume
694
Pages
108592–108592
Identifiers
DOI: 10.1016/j.abb.2020.108592
PMID: 32971033
PMCID: PMC7503072
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Inorganic/metallic core nanoparticles comprise 25% of the nanomedicines in clinical trials. • Nano-bio interactions are complex and lack of standardization in the field further limits their transition to clinical trials and beyond. • Experimental parameters play an important role along with the nanoparticle physicochemical properties in understanding their net effect on a biological system. • Standardization will aid in making fair and relevant comparisons between studies, correlate in vitro and in vivo studies better and may help towards achieving the goal of reduce, refine and replace.

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