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Understanding the influence of experimental factors on bio-interactions of nanoparticles: Towards improving correlation between in vitro and in vivo studies.

Authors
  • Natarajan, Pavithra1
  • Tomich, John M2
  • 1 Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66502, United States. , (United States)
  • 2 Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66502, United States. Electronic address: [email protected]. , (United States)
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
Nov 15, 2020
Volume
694
Pages
108592–108592
Identifiers
DOI: 10.1016/j.abb.2020.108592
PMID: 32971033
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Bionanotechnology has developed rapidly over the past two decades, owing to the extensive and versatile, functionalities and applicability of nanoparticles (NPs). Fifty-one nanomedicines have been approved by FDA since 1995, out of the many NPs based formulations developed to date. The general conformation of NPs consists of a core with ligands coating their surface, that stabilizes them and provides them with added functionalities. The physicochemical properties, especially the surface composition of NPs influence their bio-interactions to a large extent. This review discusses recent studies that help understand the nano-bio interactions of iron oxide and gold NPs with different surface compositions. We discuss the influence of the experimental factors on the outcome of the studies and, thus, the importance of standardization in the field of nanotechnology. Recent studies suggest that with careful selection of experimental parameters, it is possible to improve the positive correlation between in vitro and in vivo studies. This provides a fundamental understanding of the NPs which helps in assessing their potential toxic side effects and may aid in manipulating them further to improve their biocompatibility and biosafety. Copyright © 2020 Elsevier Inc. All rights reserved.

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