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Understanding breast cancer disparities—a multi-scale challenge

Authors
  • Hill, Hannah E.1
  • Schiemann, William P.1, 1
  • Varadan, Vinay1, 1
  • 1 Case Western Reserve University School of Medicine, Cleveland, OH
Type
Published Article
Journal
Annals of Translational Medicine
Publisher
AME Publishing Company
Publication Date
Jul 01, 2020
Volume
8
Issue
14
Identifiers
DOI: 10.21037/atm.2020.04.37
PMID: 32793750
PMCID: PMC7396752
Source
PubMed Central
Keywords
Disciplines
  • Review Article on Cancer Metastasis Molecular Signaling and Therapeutic Options
License
Unknown

Abstract

Despite convergence of overall breast cancer incidence rates between European American (EA) and African American (AA) women, disparities in mortality persist. The factors contributing to differences in mortality rates across population groups remain controversial and range from population genetics to sociodemographic influences. This review explores the complex multi-factorial nature of tumor-intrinsic and -extrinsic factors that impact the biology and clinical outcomes of breast cancer patients. In addition to summarizing the current state of breast cancer disparities research, we also motivate the development of integrative multi-scale approaches involving interdisciplinary teams to tackle this complex clinical challenge.

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