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Uncertainties, artifacts, uncontrolled experiments and incomplete evidence in modern biology.

Authors
  • Hillman, H
Type
Published Article
Journal
Physiological chemistry and physics and medical NMR
Publication Date
Jan 01, 1989
Volume
21
Issue
2
Identifiers
PMID: 2608731
Source
Medline
License
Unknown

Abstract

Major uncertainties of biological measurements in respect of parameters to which they are referred, cytochemical techniques, subcellular fractionation, light microscopy, electron microscopy, examination of cell membranes, dimensions of cells and intracellular movements, are discussed. The assumptions inherent in widely used techniques are noted and their warrant-ability examined. The impact of insufficient control experiments is shown to be considerable. A few important pieces of evidence in current generally accepted theories--mostly from neurobiology--are highlighted. All these problems represent incomplete experiments, from which it is premature to draw conclusions.

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