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[Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation].

Authors
  • 1
Type
Published Article
Journal
Nihon eiseigaku zasshi. Japanese journal of hygiene
Publication Date
Volume
62
Issue
1
Pages
3–8
Identifiers
PMID: 17334087
Source
Medline

Abstract

We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.

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