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Ultrastructural and morphometric aspects of ageing in the retinal capillaries of rats.

Authors
  • Schellini, S A
  • Gregório, E A
  • Padovani, C R
  • Spadella, C T
  • Moraes-Silva, M A
Type
Published Article
Journal
Journal of submicroscopic cytology and pathology
Publication Date
Apr 01, 1997
Volume
29
Issue
2
Pages
275–280
Identifiers
PMID: 9165721
Source
Medline
License
Unknown

Abstract

Age-related morphological, ultrastructural and morphometric changes in the capillaries of the superficial and deep plexuses of the rat retina were studied in animals aged from 3 to 15 months. Our results suggest that age-related morphological alterations start occurring in the retina of rats at about 12 months of age. Increased glycogen deposits, pinocytotic vesicles, residual bodies and cell debris were observed in both the endothelial and pericytic cells of 12- and 15-month-old animals. In addition, heterogeneous osmiophilic accumulations, electron-transparent spaces were observed in the basement membrane as well as projections of the basement membrane towards the neighboring cells. Morphometric examination of the two vascular plexuses studied did not show differences in the area of the endothelial or pericytic cells, basement membrane or vascular lumen between rats of different ages.

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