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Ultrastructural localization of acid phosphatase in human laryngeal carcinoma.

Authors
Type
Published Article
Journal
Archives of oto-rhino-laryngology
Publication Date
Volume
226
Issue
4
Pages
213–218
Identifiers
PMID: 7458755
Source
Medline

Abstract

The subcellular distribution of acid phosphatase in malignant keratinocytes of invasive laryngeal carcinoma was studied by ultrastructureal cytochemistry. The reaction product was localized in Golgi, ER, and some cytoplasmic vesicles. Acid phosphatase activity was also observed in lysosomal structures in the cortical cytoplasm of basal carcinoma cells. Extracellular acid phohphatase activity also occurred at the tumor-stroma junction in membrane-bound vesicular structures. The localization of acid phosphatase in this report is discussed in relation to acid phosphatase activity in other tumors. The findings lend further support to the important role of hydrolytic enzyme release in respect to tumor invasion into surrounding tissues.

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