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Ultrastructural changes in human skin after exposure to a pulsed laser.

Authors
  • Nakagawa, H
  • Tan, O T
  • Parrish, J A
Type
Published Article
Journal
The Journal of investigative dermatology
Publication Date
May 01, 1985
Volume
84
Issue
5
Pages
396–400
Identifiers
PMID: 3998491
Source
Medline
License
Unknown

Abstract

Selective vascular injury following irradiation using a pulsed laser source at 577 nm was examined using ultrastructural methods in the skin of 3 fair-skinned healthy human volunteers. This vascular-specific damage was confined to the papillary dermis. Red blood cells were altered in several ways. As well as an increase in the electron density, configurational distortion modified the normal biconcave forms to ameboid structures. The most interesting finding was the appearance within these altered cells of well-defined circular/oval electron-lucent areas of 800 A diameter, possibly representing a heat-fixed record of steam formation within the red blood cell. In addition, considerable degenerative changes were evident in endothelial cells and pericytes, while mast cells, neutrophils, histiocytes, and fibroblasts as well as collagen bundles immediately surrounding most laser-damaged blood vessels appeared normal.

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