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Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers.

Authors
  • Chen, Yangqing1
  • Liu, Yong2
  • Shen, Xiaodan3
  • Chang, Zhimin4
  • Tang, Longhua5
  • Dong, Wen-Fei6
  • Li, Mingyu7
  • He, Jian-Jun8
  • 1 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
  • 2 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
  • 3 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
  • 4 CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China. [email protected] , (China)
  • 5 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
  • 6 CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China. [email protected] , (China)
  • 7 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
  • 8 State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China. [email protected] , (China)
Type
Published Article
Journal
Sensors
Publisher
MDPI AG
Publication Date
Dec 15, 2015
Volume
15
Issue
12
Pages
31558–31565
Identifiers
DOI: 10.3390/s151229877
PMID: 26694390
Source
Medline
Keywords
License
Unknown

Abstract

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.

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