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Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Authors
  • Messner, Christoph B.1
  • Demichev, Vadim1, 2
  • Wendisch, Daniel3
  • Michalick, Laura4
  • White, Matthew1
  • Freiwald, Anja5, 6
  • Textoris-Taube, Kathrin5
  • Vernardis, Spyros I.1
  • Egger, Anna-Sophia1
  • Kreidl, Marco1
  • Ludwig, Daniela6
  • Kilian, Christiane6
  • Agostini, Federica6
  • Zelezniak, Aleksej1, 7
  • Thibeault, Charlotte3
  • Pfeiffer, Moritz3
  • Hippenstiel, Stefan3
  • Hocke, Andreas3
  • von Kalle, Christof8
  • Campbell, Archie9, 10
  • And 13 more
  • 1 The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, UK
  • 2 Department of Biochemistry, The University of Cambridge, Cambridge CB21GA, UK
  • 3 Charité Universitätsmedizin, Berlin, Department of Infectious Diseases and Respiratory Medicine, 10117 Berlin, Germany
  • 4 Charité Universitätsmedizin, Institute of Physiology, 10117 Berlin, Germany
  • 5 Charité Universitätsmedizin, Core Facility - High-Throughput Mass Spectrometry, 10117 Berlin, Germany
  • 6 Charité Universitätsmedizin, Department of Biochemistry, 10117 Berlin, Germany
  • 7 enburg 412 96, Sweden
  • 8 Berlin Institute of Health (BIH) and Charité Universitätsmedizin, Clinical Study Center (CSC), 10117 Berlin, Germany
  • 9 Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
  • 10 Usher Institute, University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK
  • 11 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
  • 12 MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK
  • 13 Charité Universitätsmedizin, Department of Virology, 10117 Berlin, Germany
  • 14 Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Type
Published Article
Journal
Cell Systems
Publisher
The Author(s). Published by Elsevier Inc.
Publication Date
Jun 02, 2020
Volume
11
Issue
1
Pages
11–24
Identifiers
DOI: 10.1016/j.cels.2020.05.012
PMID: 32619549
PMCID: PMC7264033
Source
PubMed Central
Keywords
License
Unknown

Abstract

Messner et al. present a standardized, low-cost, ultra-high-throughput platform for serum and plasma proteomics designed for clinical use and apply it to a cohort of hospitalized COVID-19 patients. They identify 27 potential biomarkers that are differentially expressed depending on the WHO severity grade of COVID-19.

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