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Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp.

Authors
  • Williams, Philip G
  • Yoshida, Wesley Y
  • Quon, Michael K
  • Moore, Richard E
  • Paul, Valerie J
Type
Published Article
Journal
Journal of natural products
Publication Date
May 01, 2003
Volume
66
Issue
5
Pages
651–654
Identifiers
PMID: 12762800
Source
Medline
License
Unknown

Abstract

Ulongapeptin (1), a cyclic depsipeptide, was isolated from a Palauan marine cyanobacterium Lyngbya sp. The gross structure was elucidated through one-dimensional TOCSY experiments and other spectroscopic techniques. The absolute and relative stereochemistry of the beta-amino acid, 3-amino-2-methyl-7-octynoic acid (AMO), in 1 was determined by synthesis of the saturated alpha-alkyl-beta-amino acid and Marfey's analysis of the acid hydrolysate of tetrahydro-1. Ulongapeptin (1) was cytotoxic against KB cells at an IC(50) value of 0.63 microM.

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