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The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.

Authors
  • Belledant, Anaïs1
  • Hovington, Hélène2
  • Garcia, Luciana2
  • Caron, Patrick1
  • Brisson, Hervé2
  • Villeneuve, Lyne1
  • Simonyan, David3
  • Têtu, Bernard2
  • Fradet, Yves2
  • Lacombe, Louis2
  • Guillemette, Chantal1
  • Lévesque, Eric4
  • 1 Pharmacogenomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Faculty of Pharmacy, Laval University, Québec, Canada.
  • 2 Centre Hospitalier Universitaire de Québec Research Center, Faculty of Medicine, Laval University, Québec, Canada.
  • 3 Clinical and Evaluative Research Platform, Centre Hospitalier Universitaire de Québec Research Center, Québec, Canada.
  • 4 Centre Hospitalier Universitaire de Québec Research Center, Faculty of Medicine, Laval University, Québec, Canada. Electronic address: [email protected]
Type
Published Article
Journal
European urology
Publication Date
April 2016
Volume
69
Issue
4
Pages
601–609
Identifiers
DOI: 10.1016/j.eururo.2015.06.054
PMID: 26215610
Source
Medline
Keywords
License
Unknown

Abstract

The androgen-inactivating UGT2B28 enzyme influences hormone levels, clinical and pathologic factors, and the risk of cancer progression.

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