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Ubiquitination and degradation of the inhibitors of NF-kappaB.

Authors
  • Kanarek, Naama
  • London, Nir
  • Schueler-Furman, Ora
  • Ben-Neriah, Yinon
Type
Published Article
Journal
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Publication Date
Feb 01, 2010
Volume
2
Issue
2
Identifiers
DOI: 10.1101/cshperspect.a000166
PMID: 20182612
Source
Medline
License
Unknown

Abstract

The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.

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