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Tyrosine phosphorylation and liver regeneration: A glance at intracellular transducers.

Authors
Type
Published Article
Journal
IUBMB Life
1521-6551
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
64
Issue
1
Pages
27–35
Identifiers
DOI: 10.1002/iub.576
PMID: 22184095
Source
Medline
License
Unknown

Abstract

Liver regeneration (LR) is a compensatory growth that occurs in response to resection or injury of the liver aimed at restoring the liver mass and maintaining body homeostasis. The activation of intracellular signaling pathways due to extracellular stimuli mainly reflects a highly coordinated spatial and temporal organization of phosphotyrosine-based signals generated by the concerted action of three basic functional modules, namely protein tyrosine kinases, protein tyrosine phosphatases, and the Src homology 2 (SH2) domain. In this review, we have selected a set of signaling proteins downstream of activated cytokine and growth factor receptors that highlight the multifaceted aspects of tyrosine phosphorylation with their impact on the course of LR. Besides being a process of remarkable biological interest, LR has recently emerged as a model for dissecting molecular mechanisms underlying diverse pathophysiological states, offering new perspectives in primarily, but not only, managing life-threatening liver diseases.

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