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Tyrosine aminotransferase: a transaminase among others?

Authors
  • Dietrich, J B
Type
Published Article
Journal
Cellular and molecular biology
Publication Date
Apr 01, 1992
Volume
38
Issue
2
Pages
95–114
Identifiers
PMID: 1349265
Source
Medline
License
Unknown

Abstract

Tyrosine aminotransferase (L-tyrosine: 2 oxoglutarate aminotransferase; EC 2.6.1.5; TATase) is the first enzyme in the catabolic pathway of tyrosine. The gene of this transaminase is regulated by glucocorticoid hormones as well as via the cAMP pathway. This review gives a brief survey of the structural and physico-chemical properties of this well-known protein. A comparative study of the properties of TATase with other aminotransferases is also included to analyse this molecule for itself, and not only as a marker used in studies on enzymatic induction. Finally, the regulation of the gene expression is presented, in order to underline a few important features of this model.

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