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Type II collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera.

Authors
  • Ph, Wooley
  • Hs, Luthra
  • Wp, Lafuse
  • A, Huse
  • Josh Stuart
  • Cs, David
Type
Published Article
Journal
The Journal of Immunology
Publisher
The American Association of Immunologists
Volume
134
Issue
4
Pages
2366–2374
Source
UCSC Stem Cell biomedical-ucsc
License
Unknown

Abstract

Pretreatment of mice genetically susceptible to type II collagen-induced arthritis (CIA) with monoclonal or polyclonal antisera specific for I region gene products (Ia antigens) suppressed or delayed the onset of CIA, whereas pretreatment with anti-Ia to an irrelevant haplotype was without effect. The humoral response to type II collagen was transiently depressed 14 days after immunization but antibody levels did not differ significantly after 28 days. The peak delayed-type hypersensitivity to type II collagen was unaffected by anti-Ia treatment. Monoclonal antibody of one anti-Ia specificity enhanced both the antibody response and the arthritis incidence in one mouse strain.

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