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Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Authors
  • Li, Shi-fang
  • Gong, Mei-jiao
  • Zhao, Fu-rong
  • Shao, Jun-jun
  • Xie, Yin-li
  • Zhang, Yong-guang
  • Chang, Hui-yun
Type
Published Article
Journal
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Publication Date
Dec 11, 2018
Volume
51
Issue
5
Pages
2377–2396
Identifiers
DOI: 10.1159/000495897
PMID: 30537741
Source
Karger
Keywords
License
Green
External links

Abstract

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

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